Phil Neville and Salvador Gonzalez (Voro) have been placed in charge of first-team affairs at Valencia until further notice, following the resignation of Nuno on Sunday night.
Nuno announced his departure after Sunday’s 1-0 loss to Sevilla, but said he had already informed chairman Peter Lim of his decision before the game.
Neville and Voro have been told to prepare to take charge of training on Tuesday according to reports in AS.
AS said the situation would continue “until further notice” and the two coaches would oversee preparations for the midweek Copa del Rey match against Barakaldo.
Nuno, 41, leaves the side ninth in Primera Liga and third in Group H of the Champions League.
However, the Portuguese said the club had not make the progress he had hoped for.
“We are all in agreement that the current situation is not good, and that we must all do what is best for the club; this has always been my intention,” he said.
“I want to thank all the players who I have managed at the club for their work. I also want to thank Peter Lim, who is – and will continue to be – a friend of mine, and the fans of Valencia CF.
“I ask that the fans continue to support the youngest squad in La Liga. Tomorrow we will give more details. I understand that the issue is pertinent, but I do not want to say too much in this regard.”
Neville joined Valencia as a coach in July, having previously been first-team coach under David Moyes at Manchester United.